Liverpool’s 2-1 defeat to Manchester United last weekend - only Jurgen Klopp’s fourth league loss in 2017/18 - has them suddenly looking a little vulnerable in the race for this year’s top four.
While they could have moved into second place with a victory at Old Trafford, they instead slipped one place and one point behind Tottenham into fourth and are now just four points in front of Chelsea as the race heats up.
They welcome a Watford side to Anfield that played better than the 3-0 scoreline against Arsenal last time out indicates and which has just about done enough to secure its Premier League survival, so can take the fight up to their more fancied opponents.
Arsenal vs Watford
The situation just goes from bad to worse at Arsenal and must be scarcely believable to their legion of fans.
They are currently riding a four-game losing streak across all competitions. Consecutive defeats to Manchester City, including the League Cup final, are poor results but in some ways excusable against the high-flyers from up north.
But with all due respect to Brighton and Hove Albion, a 2-1 defeat to the promoted side is borderline unforgivable considering Arsenal’s lofty standing and has led to all sorts of finger pointing, particularly, of course, at manager Arsene Wenger.
They take on a Watford side that must like its chances in this one, winning three of its past four Premier League games, including that famous 4-1 win over Chelsea and consecutive 1-0 victories over Everton and West Brom.
Sitting comfortably in ninth, the Hornets have little to lose in this game and should throw everything at their beleaguered opponents.
Manchester United vs Liverpool
Matches between these two teams, among the biggest rivals in all of global sport, always have that extra layer of spice.
But considering they are currently occupying second and third places on the English Premier League table, with United one spot and just two points above the Reds, there is even more on the line than usual.
With many expecting Jose Mourinho’s side to slip-up in the tight race for Champions League qualification, they fought back from going a goal behind to overcome Chelsea 2-1 last week and keep the wolves at bay for another week.
It was an impressive display and one that should give them confidence in what appears a four-way battle for the three remaining positions behind runaway leaders Manchester City. It now seems clear one of United, Liverpool, Chelsea or Tottenham will join Arsenal on the top-four scrapheap, with the Gunners falling further away after their loss to City.
Liverpool have also been in strong form, brushing aside West Ham with consummate ease last week, so both sides will like their chances in this match.
Manchester City vs Chelsea
A morale-sapping defeat to Manchester United at Old Trafford means that Antonio Conte’s men have fallen out of the top four, with London rivals Tottenham Hotspur leapfrogging them with a last-gasp 1-0 win over Crystal Palace.
Chelsea have been on a worrying run of form, with the Blues having lost three of their last five games. They took the lead at Old Trafford courtesy of a Willian goal, but after the home side got themselves back in the game, it only looked like there was going to be one winner.
Manchester City on the other hand, seem to be running away with the title. Having amassed a seemingly unassailable lead over cross-town rivals Manchester United, the Citizens took home their first piece of silverware of the season last weekend, thumping Arsenal 3-0 in the EFL Cup final.
A big win over Chelsea would all but cement their status as champions-elect and send a warning shot to the rest of the league.
Liverpool vs Newcastle United
Liverpool have responded well since consecutive defeats to Swansea City and West Brom in the Premier League and FA Cup respectively back in January, reeling off a five-match unbeaten run in all competitions.
They have also returned to their free-scoring ways, registering 16 goals in that stretch, while their defence also seems to be slowly improving, conceding just three times across those five matches, two of which came in an action-packed 2-2 draw with Tottenham.
None of that will make very pleasant reading for Newcastle fans, with their club doing all it can to stave off what is still a very real threat of relegation.
The Magpies are riding a four-match unbeaten run of their own, however, which included an uplifting 1-0 victory over Manchester United. Yet they threw away a two-goal lead with just 10 minutes remaining in their away clash with Bournemouth on Saturday to sit just two points above 18th-placed Swansea City in an extraordinarily tight fight for survival.
Arsenal vs Manchester City
Following a shock FA Cup defeat to League One side Wigan Athletic last week, ending Manchester City’s bid for a quadruple collection of titles this campaign, there were the first small signs of trouble in their otherwise sensational season.
But any concerns over their form were quickly put to rest following their comprehensive 3-0 victory over Arsenal in Sunday’s League Cup final, giving manager Pep Guardiola his first piece of silverware on English soil.