This is a clash which promises fireworks on the pitch and probably on the touchline as well - with old foes Jose Mourinho and Antonio Conte reunited.
The recent league form of both Manchester United and Chelsea have been patchy to say the least. The Red Devils have lost their last two away games - falling to a 2-0 defeat to Spurs at Wembley and losing 1-0 to relegation strugglers Newcastle United. Chelsea haven’t been at their best either, losing two of their past three games in the Premier League, crumbling to defeats against Watford (4-1) and Bournemouth (3-0).
With Chelsea having won the reverse fixture 1-0, the onus will be on Mourinho’s men to take revenge. A win would also mean that they extend their lead over the fourth-placed Blues, who are now trailing the second-placed Manchester United by three points.
Manchester City vs Leicester City
It would be premature to call Man City’s recent run of results a slump, but it must be said that Pep Guardiola’s men have dropped more points than they would have liked after a scintillating start to the season.
The runaway leaders only picked up 55 from a possible 57 before Christmas, but since then have only chalked up 14 from 21. City’s recent away draw with Burnley would also have proved a disappointing outing, having spurned a number of chances to see off the game, before being punished by the home side.
Up against the title favourites will be Claude Puel’s Leicester, who have been rather inconsistent in the league. Currently in eighth spot, the Foxes can be a slick attacking force on their day, but having lost one and drawn one of their past two games, they will be hoping that they can somehow upset the odds against the Man City juggernaut.
Tottenham Hotspur vs Arsenal
The balance of power has slowly been shifting in North London, with Tottenham gradually closing the gap and then finally passing the Gunners in the Premier League pecking order last season.
Now Mauricio Pochettino’s side has an opportunity to widen the gap between the two teams in the crucial race for the top four.
While Manchester City have broken clear of the pack, it is a condensed race for the remaining Champions League qualifying positions.
If Arsene Wenger has any hope of getting his Arsenal troops back into contention for the top four, they will need all three points at Wembley.
Liverpool vs. Tottenham Hotspurs
Tottenham are in much the same predicament and will also want to maintain their top-four status after making great strides in recent seasons. The outcome of this fixture could have a big say in both teams’ fortunes over the closing weeks of the season.
Liverpool are poised at a critical moment in their 2017/18 campaign. What was once so promising has boiled down to top-four- or-bust after being knocked out of the FA Cup, unless they can pull off an improbable Champions League run.
Arsenal vs. Everton
Everton are on a disappointing run of form, and will need to return to winning ways. Sam Allardyce may have steadied the ship at Goodison Park, but they will need to put together a string of wins in order to replicate last season’s seventh-placed finish.
There is some positivity returning to the Emirates again, as the Gunners have ensured the departing Alexis Sanchez did not leave a huge void, signing another player capable of creating magic, albeit with less attitude – Henrikh Mkhitaryan. The Armenian international simply was unable to cement down a starting spot at Manchester United, and his arrival will be welcomed.
Manchester United vs Huddersfield Town
The Terriers are riding plenty of momentum, but the Premier League campaign is one of the more arduous in world football and they struggled for results through much of November and early December, including a 4-0 thrashing at the hands of a Bournemouth side that played the entire second half with 10 men.
It’s no surprise that Huddersfield have had their issues in their first season in the big time. Undeniably their highlight so far was their stunning victory over Manchester United at John Smith Stadium back in October.
They are coming up against a United outfit that will want to set the record straight from that humbling result in October, knowing they need to keep winning to hold off the chasing pack in this year’s incredibly tight race for the top four.
Tottenham vs. Manchester United
This will be a tight contest between Jose Mourinho's Manchester United and Mauricio Pochettino's Spurs.
Spurs' last defeat also came against a rampant Manchester City outfit, when they were thumped 4-1, but since then they too have put together a nifty six-game unbeaten run of their own.
Mourinho's men are on a decent run in the league, unbeaten in their last eight (five wins, three draws) - their last defeat in the Premier League coming against table-toppers City. But they will need to turn those draws into wins if they are to stand any chance of staying in the title race.